Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease

Part of paid clinical trials in Atlanta, Georgia.

Sponsor
Emory University
Study ID
NCT06484244
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • 5 Sessions of Split-belt Treadmill-based Locomotor Adaptation — OTHER
    Participants will complete 5 sessions of split-belt treadmill-based locomotor adaptation. The split-belt instrumented treadmill allows the two belt speeds to be operated independently, enabling different belt speeds for each leg. The split-belt walking assessment will consist of 3 phases: baseline phase in which the belts operated at the same speed (Pre-tied, 2-minutes), a phase in which the belts operated at different speeds (Split-belt, 15-minutes), and a final phase in which the belts operated at the same speed (Post-tied, 4-minutes).

Study Details

In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor impairments. It is also an important therapeutic target for exercise-based interventions to improve walking function. The overall goal of this study is to understand the effects of MCI and AD on locomotor adaptation and walking function.

Key Dates

Start date
Jul 22, 2025
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
10 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Split-beltTreadmill-based Locomotor Adaptation in Older Adults with MCI
    Older adults with mild cognitive impairment (MCI) complete 5 split-belt treadmill walking exercise sessions over a 2-week period.
  • Experimental: Split-beltTreadmill-based Locomotor Adaptation in Older Adults with AD
    Older adults with Alzheimer's Disease (AD) complete 5 split-belt treadmill walking exercise sessions over a 2-week period.

Primary Outcome Measure

Change in Adaptation Magnitude Assessed as Peak Step Length Symmetry [ Time Frame: Baseline (Pre-training), Week 2 (Post-training) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Emory Rehabilitation HospitalAtlantaGeorgia30322-

Find similar trials in Atlanta, GA

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Emory Rehabilitation Hospital· Atlanta, GA

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