A Study of Sacituzumab Govitecan in People With Mesothelioma

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06477419
Phase
PHASE2
Status
Recruiting
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Conditions

  • Mesothelioma
  • Mesothelioma; Pleura
  • Mesotheliomas Pleural

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Sacituzumab govitecan-hziy — DRUG
    After enrollment, participants will receive SG until disease progression or intolerable toxicity.

Study Details

Participants will receive sacituzumab govitecan until their disease gets worse (progresses), they have severe side effects and cannot continue study treatment, or the participants or the study doctor thinks it's in your best interest to stop treatment.

Key Dates

Start date
Jun 21, 2024
Status verified
May 2026
Primary completion
Jun 21, 2029
Completion
Jun 21, 2029

Study Design

Enrollment
33 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with Mesothelioma
    Participants will have pathologically confirmed diffuse pleural mesothelioma. Patients will undergo cross-sectional imaging after the first 2 cycles and subsequently after every 3 cycles until disease progression. Biopsies will take place at screening, prior to cycle 3, and an optional biopsy at the end of treatment if consent was obtained and deemed to be safe and feasible. Patients treated on study who are removed prior to the Cycle 3 tumor assessment will be evaluated for toxicity only and replaced. All patients treated past the Cycle 3 tumor assessment will be include in the toxicity and efficacy assessments.

Primary Outcome Measure

Overall Response Rate [ Time Frame: 2 years ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking RidgeBasking RidgeNew Jersey07920
Michael Offin, MD
646-449-1778
Memorial Sloan Kettering MonmouthMiddletownNew Jersey07748
Michael Offin, MD
646-608-3763
Memorial Sloan Kettering BergenMontvaleNew Jersey07645
Michael Offin, MD
646-608-3763
Memorial Sloan Kettering Cancer Center @ CommackCommackNew York11725
Michael Offin, MD
646-608-3763
Memorial Sloan Kettering WestchesterHarrisonNew York10604
Michael Offin, MD
646-608-3763
Memorial Sloan - Kettering Cancer CenterNew YorkNew York10021
Michael Offin, MD
646-608-3763
Memorial Sloan Kettering NassauUniondaleNew York11553
Michael Offin, MD
646-608-3763

Find similar trials in Basking Ridge, NJ

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Memorial Sloan Kettering Basking Ridge· Basking Ridge, NJMemorial Sloan Kettering Monmouth· Middletown, NJMemorial Sloan Kettering Bergen· Montvale, NJMemorial Sloan Kettering Cancer Center @ Commack· Commack, NYMemorial Sloan Kettering Westchester· Harrison, NYMemorial Sloan - Kettering Cancer Center· New York, NY

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