A Study to Evaluate the Safety, Tolerability, and Efficacy of Escalating Doses of BMS-986463 in Participants With Select Advanced Malignant Tumors.

Part of paid clinical trials in Los Angeles, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT06476808
Phase
PHASE1
Status
Recruiting
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Conditions

  • High-grade Serous Ovarian Carcinoma (HGSOC)
  • Non-small Cell Lung Cancer (NSCLC)
  • Uterine Serous Carcinoma (USC)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • BMS-986463 — DRUG
    Specified dose on specified days

Study Details

The purpose of this study is to evaluate the safety, tolerability, and efficacy of escalating doses of BMS-986463 in participants with select advanced malignant tumors.

Key Dates

Start date
Sep 6, 2024
Status verified
Apr 2026
Primary completion
Dec 19, 2028
Completion
Dec 19, 2028

Study Design

Enrollment
240 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm 1: Dose Escalation
  • Experimental: Arm 2: Dose Expansion

Primary Outcome Measure

Number of participants with adverse events (AEs) [ Time Frame: Up to 108 weeks ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain NCT # and Site #.

Locations (6)

FacilityCityStateZIPSite coordinators
USC/Norris Comprehensive Cancer CenterLos AngelesCalifornia90033
Anastasia Martynova, Site 0003
310-226-2905
Valkyrie Clinical TrialsLos AngelesCalifornia90067
David Berz, Site 0006
424-535-1874
John Theurer Cancer Center at Hackensack University Medical CenterHackensackNew Jersey07601
Martin Gutierrez, Site 0001
551-996-5863
Local Institution - 0045ColumbusOhio43210
Site 0045
Local Institution - 0046DallasTexas75390
Site 0046
Local Institution - 0049HoustonTexas77054
Site 0049

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By research site
USC/Norris Comprehensive Cancer Center· Los Angeles, CAValkyrie Clinical Trials· Los Angeles, CAJohn Theurer Cancer Center at Hackensack University Medical Center· Hackensack, NJLocal Institution - 0045· Columbus, OHLocal Institution - 0046· Dallas, TXLocal Institution - 0049· Houston, TX

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