UnityPhilly Response App for Overdose Reversal

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Drexel University
Study ID
NCT06466005
Status
Recruiting
Apply to this trial

Conditions

  • Opioid Overdose

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • UnityPhilly app — OTHER
    UnityPhilly automatically connects bystanders and victims of opioid overdose with nearby community members who can respond immediately with naloxone.

Study Details

The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app. The main hypotheses to answer are: Hypothesis 1: UnityPhilly signal rates relative to EMS calls will increase over time. The primary outcome will be assessed as the total number of overdoses signaled by participants relative to all overdose-related EMS calls, per year. Hypothesis 2: The number of cases where a nearby UnityPhilly participant successfully reverses an overdose with naloxone will increase over time. The primary outcome will be assessed as the number of successful reversals relative to the total number of responder arrivals, per year. Participants will be supplied with the UnityPhilly app, training on how to use the app and respond to an opioid overdose using naloxone, and respond to follow up surveys about their experiences.

Key Dates

Start date
Sep 16, 2025
Status verified
May 2026
Primary completion
Dec 31, 2027
Completion
Jul 31, 2028

Study Design

Enrollment
450 participants (estimated)

Arms

  • Arm: Active non-medical opioid user
    Person who has used an opioid, e.g., heroin, fentanyl, non-medically in the past 30 days.
  • Arm: Active prescription medical opioid user
    Person who has used an opioid, e.g., hydrocodone, with a medical prescription in the past 30 days.
  • Arm: Person in recovery from opioid misuse
    Person who formerly used opioids non-medically and/or is on opioid replacement therapy.
  • Arm: Caregiver/family members of groups 1, 2, 3
    Person who is caring for or a family member of active non-medical user, medical user, or person in recovery.
  • Arm: Concerned community member
    Person in the community who is concerned about the opioid overdose crisis and is interested addressing the problem.

Primary Outcome Measure

Rate of Overdoses Signaled [ Time Frame: 2 year period ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Drexel UniversityPhiladelphiaPennsylvania19104
Stephen Lankenau, PhD
[email protected]
323-326-6438
Kushal Naik, MPH
[email protected]

Find similar trials in Philadelphia, PA

By research site
Drexel University· Philadelphia, PA

Related Studies