Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT06458153
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Neural responses to speech functional localizer — BEHAVIORAL
    Measuring speech-related brain activity using fMRI during a speech listening task.
  • Neural responses to silent articulation — BEHAVIORAL
    Measuring speech-related brain activity using fMRI during a silent articulation task.
  • Neural responses to self vs. externally generated speech — BEHAVIORAL
    Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
  • Event-related potentials for speech — BEHAVIORAL
    Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
  • Neural responses to induced speech errors — BEHAVIORAL
    Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
  • Neural responses to sensory-motor adaptation — BEHAVIORAL
    Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
  • Speech production behaviors — BEHAVIORAL
    Behavioral measurements of speech during reading passages and words
  • Auditory acuity testing — BEHAVIORAL
    Measurements of auditory acuity during listening tasks.
  • Neural responses to learning a non-speech auditory motor behavior — BEHAVIORAL
    Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.

Study Details

The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).

Key Dates

Start date
May 27, 2025
Status verified
Jun 2025
Primary completion
Jul 31, 2028
Completion
Jul 31, 2028

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Speech behavior and functional imaging
    Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.

Primary Outcome Measure

Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech [ Time Frame: One session lasting 2-3 hours, within 12 months of enrollment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15260
Jason Bohland, Ph.D.
[email protected]
412-383-3416
Alexander Ocampo, BA
[email protected]
Jason W Bohland, Ph.D. (PRINCIPAL_INVESTIGATOR)

Find similar trials in Pittsburgh, PA

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
University of Pittsburgh· Pittsburgh, PA

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