Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Part of paid clinical trials in Sterling Heights, Michigan.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT06427538
Status
Recruiting
Apply to this trial

Conditions

  • Empyema, Pleural
  • Pleural Infection

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Saline Flush — OTHER
    sterile saline 20 mL flushed into their catheter by trained nurses or study team members every 6 ± 2 hours

Study Details

Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material. For this reason, it is thought that flushing the chest drain with saline solution, can help maintain the patency of the tube. This proposed study will evaluate the impact of regular chest drain flushing on the length of time to chest tube removal and total hospitalization as well as improvement in chest imaging and the need for additional interventions on the infected space.

Key Dates

Start date
Jun 21, 2024
Status verified
Feb 2026
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
96 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Saline Intervention Arm
    Patient will receive 20 mL sterile saline flushes into their catheter by study team members every 6 ± 2 hours. If patients are receiving intrapleural tissue plasminogen activator and deoxyribonuclease therapy, each treatment will be considered one flush.
  • No Intervention: No Intervention Arm
    Patient will receive a saline flush as needed, to restore patency of a chest tube considered blocked. No routine flushes will be administered.

Primary Outcome Measure

Time to chest tube removal [ Time Frame: up to 3 months ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
Henry FordSterling HeightsMichigan48310
Labib Debiane, MD
[email protected]
800-436-7936
Creighton UniversityOmahaNebraska68124
Zachary S DePew, MD
[email protected]
402-717-9600
Mount SinaiNew YorkNew York10029
Udit S Chaddha
[email protected]
212-241-5656
Vanderbilt University Medical CenterNashvilleTennessee37203-
Virginia Commonwealth UniversityRichmondVirginia23298
Danai Khemasuwan
[email protected]
804-828-6396

Find similar trials in Sterling Heights, MI

By research site
Henry Ford· Sterling Heights, MICreighton University· Omaha, NEMount Sinai· New York, NYVanderbilt University Medical Center· Nashville, TNVirginia Commonwealth University· Richmond, VA

Related Studies