Genetics in the Progression of Nephropathies

Sponsor
Ospedale San Raffaele
Study ID
NCT06416761
Status
Recruiting
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Conditions

  • ADPKD
  • AKI
  • Bone Marrow Transplant Complications
  • CKD
  • CKD (Chronic Kidney Disease) Stage 5D
  • Ckd-Mbd
  • Hematologic Malignancy
  • Hypertension

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • genetic polymorphisms — GENETIC

Study Details

This study evaluates the role of genetic in the development and progression of different nephropaties with particular attention to: * AKI * CKD * Hypertension * ADPKD * CKD-MBD * Patients with decompensated heart failure undergoing either medical or surgery therapy * Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation * glomerular diseases

Key Dates

Start date
May 19, 2006
Status verified
May 2024
Primary completion
May 19, 2040
Completion
May 19, 2041

Study Design

Enrollment
10,000 participants (estimated)

Arms

  • Arm: Patients with acute or chronic nephropathy
    1. Patients with chronic nephropathies 2. Patients with acute nephropathy 3. Patients with nephrectomy 4. Candidate Patients to major surgery 5. Patients with decompensated heart failure undergoing either medical or surgical therapy 6. Acute critically ill patients (e.g sepsis, post-operative) 7. Patients with hypertension 8. Patients with hematologic cancer exposed to chemotherapeutic agents or undergoing allogeneic bone marrow transplantation. 9. Long-term surviving patients who received bone marrow transplantation.

Primary Outcome Measure

difference in glomerular filtration rate according to genetic profile [ Time Frame: from days to 35 years ]

Central Contacts

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