The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Massachusetts General Hospital
Study ID
NCT06412172
Status
Recruiting
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Conditions

  • Pulmonary Neoplasm
  • Recurrent Respiratory Papillomatosis

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Study Details

Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11. Since RRP is an orphan disease, it is an understudied disease entity with correspondingly few treatment options. The investigators hypothesize that by understanding the biology of RRP and the failed host immune responses against HPV, novel and rational therapies can be developed. This study will examine the genetic and immunologic alterations found in these rare tumors and distant metastatic involved sites (such as the lung) in patients diagnosed with RRP.

Key Dates

Start date
Apr 15, 2024
Status verified
Aug 2025
Primary completion
Apr 14, 2026
Completion
Apr 15, 2030

Study Design

Enrollment
100 participants (estimated)

Primary Outcome Measure

Number of Participants with HPV 6 or 11 infection in the pulmonary lesions [ Time Frame: 24 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale School of MedicineNew HavenConnecticut06520
Sara Pai, MD, PhD

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Yale School of Medicine· New Haven, CT

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