Mood and Decision-making in Methamphetamine Use Disorder

Part of paid clinical trials in Tulsa, Oklahoma.

Sponsor
Laureate Institute for Brain Research, Inc.
Study ID
NCT06410196
Status
Recruiting
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Conditions

  • Methamphetamine Abuse

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Mood modulation — BEHAVIORAL
    Autobiographical memory recall designed to modulate mood and affective state by reminiscing about personal life events

Study Details

In this project, the investigators examine behavior and associated brain activity during explore-exploit decision-making tasks performed pre- and post-modulation of affective state using autobiographical memory recall. The investigators hypothesize that a positive memory recall will reduce negative affective state, reduce explore-exploit biases and normalize the associated brain activity. The investigators propose a randomized double-blind, sham-controlled trial of positive autobiographical memory recall with 80 adults (n=40 per arm) with methamphetamine use disorder (MUD) currently involved in abstinence only treatment centers.

Key Dates

Start date
Jul 26, 2024
Status verified
Sep 2025
Primary completion
Jul 1, 2027
Completion
Jul 1, 2027

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Positive mood modulation
    Use of happy/positive autobiographical memories which are vivid, emotionally pleasurable and not drug-related, as assessed by individual interview and ratings
  • Sham Comparator: Neutral mood modulation
    Use of neutral/procedural autobiographical memories which are vivid, emotionally neutral and not drug-related, as assessed by individual interview and ratings

Primary Outcome Measure

Current affective state [ Time Frame: Change from pre-intervention (baseline) to post-intervention (90min later) on study day 1 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Laureate Institute for Brain ResearchTulsaOklahoma74136
Maëlle CM Gueguen, PhD
[email protected]
918-502-5155

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Laureate Institute for Brain Research· Tulsa, OK

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