Cardiac-Control Affecting Learning Through Mindfulness (CALM)

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT06410157
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
50 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Daily practice — BEHAVIORAL
    Participants will be asked to undergo daily mindfulness practice while regulating (either increase or decrease) heart rate oscillation.

Study Details

Some types of meditation lead heart rate to become more steady as breathing quiets whereas others lead to large heart rate swings up and down (oscillations) as breathing becomes deeper and slower. The current study is designed to investigate how daily mindfulness practice with heart rate biofeedback during breathing in a pattern that either increases or decreases heart rate oscillation affect attention and memory and blood biomarkers associated with Alzheimer's disease.

Key Dates

Start date
Jan 14, 2025
Status verified
May 2026
Primary completion
Nov 30, 2027
Completion
Nov 30, 2027

Study Design

Enrollment
240 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Increase Oscillation
    Participants will breath at a slow "resonance" frequency during a breath-focused mindfulness practice and receive biofeedback to increase heart rate oscillation.
  • Experimental: Decrease Oscillation
    Participants' breathing will not be fixed to particular frequency during a breath-focused mindfulness practice and they will receive biofeedback to decrease heart rate oscillation.

Primary Outcome Measure

Change in plasma amyloid-beta 42 levels [ Time Frame: Week 1 and Week 10 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Southern CaliforniaLos AngelesCalifornia90089
Emotion & Cognition Lab Coordinator
[email protected]
213-740-9543

Find similar trials in Los Angeles, CA

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
University of Southern California· Los Angeles, CA

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