Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness

Conditions

• Fluid Responsiveness

Eligibility Criteria

Sex

ALL

Age

30 Years - 90 Years

Healthy Volunteers

Not accepted

Interventions

• Passive leg raise, SVI via bioreactance, Echo based VTI — DIAGNOSTIC_TEST
  No interventions other than fluid challenge

Study Details

In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.

Key Dates

Start date

Jul 1, 2023

Status verified

Aug 2024

Primary completion

Jun 30, 2025

Completion

Jun 30, 2025

Study Design

Enrollment

64 participants (estimated)

Arms

• Arm: Fluid responder
  Stability of vasopressor dose with maximum of 500 cc of crystalloids
• Arm: Fluid non responder
  Escalating dose of vasopressors despite 1 L of crystalloid fluid challenge

Primary Outcome Measure

Vasopressor dose in Nor-epinephrine equivalents (NE) measured as mcg/kg/min [ Time Frame: 3 hours after the initial passive leg raise ]

Central Contacts

• Ramakanth Pata
  320-240-2207
  [email protected]

Locations (1)

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