A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

Part of paid clinical trials in St Louis, Missouri.

Sponsor
University College, London
Study ID
NCT06372821
Phase
PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Alzheimer Disease
  • Autosomal Dominant Alzheimer Disease Due to Mutation of Amyloid Precursor Protein (Disorder)
  • Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)
  • Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)

Eligibility Criteria

Sex
ALL
Age
21 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • NIO752 — DRUG
    Antisense oligonucleotide
  • Placebo — OTHER
    Saline

Study Details

This study will assess if drug (NIO752) reduces production of a protein, tau, by the brain. Normally tau maintains the internal skeleton of nerve cells. In Alzheimer's disease (AD) it builds up in the brain, causing damage. Abnormal tau proteins cling to each other forming 'tangles' inside nerve cells, which interfere with how the nerve cells work, and eventually die. This is what causes the symptoms of dementia. It is thought that NIO752 reduces production of tau.

Key Dates

Start date
Nov 18, 2024
Status verified
Jan 2026
Primary completion
Jul 31, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
10 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: NIO752
    Intrathecal administration.
  • Placebo Comparator: Saline
    10mL of saline (placebo) is administered intrathecally.

Primary Outcome Measure

Tau synthesis rate inhibition in individuals with sporadic AD and ADAD [ Time Frame: Day 23 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University in St. LouisSt LouisMissouri63110
Tina Nolte
[email protected]
314-362-3839
Nupur Ghoshal, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in St Louis, MO

By condition
Alzheimer's disease
By specialty
NeurologyDementia careBrain disordersGeriatrics
By research site
Washington University in St. Louis· St Louis, MO

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