Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis

Conditions

• Arthritis of Carpometacarpal Joint of Left Thumb
• Arthritis of Carpometacarpal Joint of Right Thumb

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Curcumin — DRUG
  500 mg capsule twice daily
• Placebo — DRUG
  capsule twice daily

Study Details

The goal of this clinical trial is to learn about the use of turmeric (Curcumin) as a treatment for pain of thumb-joint arthritis. Turmeric is commonly being used as an over-the-counter treatment for musculoskeletal pain. Clinical trials have demonstrated a pain-relief benefit for knee osteoarthritis, however no clinical trial has been performed to establish efficacy of curcumin in humans for thumb-joint arthritis. The main question\[s\] it aims to answer are: * Is Turmeric more effective than placebo at relieving pain for thumb-joint arthritis? A placebo is a look-alike substance that contains no active drug. * Is Turmeric more effective than placebo at improving patient-reported outcomes for CMC arthritis? * Is Turmeric safe for participants with thumb-joint arthritis? Participants will: * take 4 weeks of daily Turmeric capsules, * take 4 weeks of daily placebo capsules * answer daily surveys about how they are feeling and functioning.

Key Dates

Start date

Feb 1, 2025

Status verified

Dec 2025

Primary completion

Feb 28, 2026

Completion

Feb 28, 2026

Study Design

Enrollment

100 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Arms

• Experimental: Oral curcumin
  Oral curcumin 500 mg capsules taken twice each day for 4 weeks.
• Placebo Comparator: Placebo
  Oral placebo capsules taken twice each day for 4 weeks.

Primary Outcome Measure

Change from Baseline in Pain on the Visual Analog Pain (VAS) Score [ Time Frame: Baseline and Week 4, Week 6 ]

Locations (1)

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