Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)

Part of paid clinical trials in Scottsdale, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT06354660
Phase
PHASE3
Status
Completed

Conditions

  • Diabetes Type 2

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Retatrutide — DRUG
    Administered SC.
  • Placebo — DRUG
    Administered SC.

Study Details

The purpose of this study is to investigate the efficacy and safety of retatrutide compared with placebo in participants with Type 2 Diabetes and inadequate glycemic control. The study will last about 11 months and may include up to 11 visits.

Key Dates

Start date
Apr 10, 2024
Status verified
Mar 2026
Primary completion
Jan 22, 2026
Completion
Feb 20, 2026

Study Design

Enrollment
537 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Retatrutide Dose Level 1
    Participants will receive retatrutide administered subcutaneously (SC).
  • Experimental: Retatrutide Dose Level 2
    Participants will receive retatrutide administered SC.
  • Experimental: Retatrutide Dose Level 3
    Participants will receive retatrutide administered SC.
  • Placebo Comparator: Placebo
    Participants will receive placebo administered SC.

Primary Outcome Measure

Change from Baseline in Hemoglobin A1c (HbA1c) (%) [ Time Frame: Baseline, Week 40 ]

Locations (29)

FacilityCityStateZIPSite coordinators
Scottsdale Clinical TrialsScottsdaleArizona85260-
Tucson Clinical Research InstituteTucsonArizona85712-
San Fernando Valley Health InstituteCanoga ParkCalifornia91304-
Ark Clinical ResearchLong BeachCalifornia90815-
Northeast Research Institute (NERI)Fleming IslandFlorida32003-
Ezy Medical ResearchMiamiFlorida33175-
New Horizon Research CenterMiamiFlorida33165-
Clinical Research of Central FloridaWinter HavenFlorida33880-
Trinity Research CentersMariettaGeorgia30064-
Cotton O'Neil Clinical Research CenterTopekaKansas66606-
NECCR PrimaCare ResearchFall RiverMassachusetts02721-
Clinical Research ProfessionalsChesterfieldMissouri63005-
Boeson Research MSOMissoulaMontana59804-
NJ MedCare & NJ HeartLindenNew Jersey07036-
Accellacare - Wilmington - 1917 Tradd CourtWilmingtonNorth Carolina28401-
Providence Health Partners-Center for Clinical ResearchDaytonOhio45439-
Clinical Research of PhiladelphiaPhiladelphiaPennsylvania19114-
Preferred Primary Care PhysiciansUniontownPennsylvania15401-
Delricht Research - Tobias Gadson Boulevard - CharlestonCharlestonSouth Carolina29407-
Lifedoc Research - Lenox Park DriveMemphisTennessee38115-
Clinical Research Associates IncNashvilleTennessee37203-
Velocity Clinical Research, DallasDallasTexas75230-
Prime Revival Research Institute, LLCFlower MoundTexas75028-
Valley Institute of Research - Fort WorthFort WorthTexas76164-
Consano Clinical Research, LLCShavano ParkTexas78231-
Texas Valley Clinical ResearchWeslacoTexas78596-
Manassas Clinical Research CenterManassasVirginia20110-
MultiCare Rockwood Cheney ClinicCheneyWashington99004-
Eastside Research AssociatesRedmondWashington98052-

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Scottsdale Clinical Trials· Scottsdale, AZTucson Clinical Research Institute· Tucson, AZSan Fernando Valley Health Institute· Canoga Park, CAArk Clinical Research· Long Beach, CANortheast Research Institute (NERI)· Fleming Island, FLEzy Medical Research· Miami, FL

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