PO Methadone Ortho Outpatient

Conditions

• Arthroscopic Hip Repair
• Arthroscopic Knee Repair

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Methadone group — DRUG
  5mg PO methadone for participants \<50kg or 10mg PO methadone for participants \>50kg
• Placebo — DRUG
  sugar pill that is identical look-alike to study drug

Study Details

The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage. The main questions it aims to answer are: Does oral methadone improve post-operative pain scores as compared to standard treatment? Does oral methadone lead to reduced use of post-operative and post-discharge opioid usage as compared to the current standard treatment? Researchers will compare oral methadone to a placebo (a look-alike substance that contains no drug) to assess the questions above. Participants will: Receive either oral methadone or a look-alike placebo before surgery Receive standard intraoperative and immediate post-operative pain control at the anesthesiologist's discretion Be asked about their pain levels in the recovery area Keep a diary of pain and opioid usage over the first 2 days after surgery

Key Dates

Start date

May 1, 2025

Status verified

Mar 2025

Primary completion

Dec 1, 2025

Completion

Dec 15, 2025

Study Design

Enrollment

100 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Placebo Comparator: Control
  placebo sugar pill and standard intraoperative pain control using short-acting opioids, with drug choice and dosing at the practitioner's discretion
• Experimental: Interventional
  5mg PO methadone for participants \<50kg or 10mg PO methadone for participants \>50kg

Primary Outcome Measure

Post-op opioid usage [ Time Frame: at Post-Anesthesia Care Unit arrival, post-operative 30 minutes, post-op 60 minutes, post-operative day 1, and post-operative day 2 ]

Central Contacts

• Alexander Chen, M.D.
  323-442-7400
  [email protected]

Locations (1)

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