A Study of 2141-V11 in Combination With Standard Treatments in People With Prostate Cancer

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06347705
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • 2141-V11 Antibody — BIOLOGICAL
    2141-V11 Antibody: Intratumor injection

Study Details

The purpose of this study is to see whether combining 2141-V11 with various standard treatments is an effective treatment approach for prostate cancer. 2141-V11 works by activating the immune system to find and kill cancer cells. Researchers will look at whether this treatment approach is able to completely get rid of cancer in participants, and they will check for the presence of minimal residual disease (MRD) in participants. MRD is a small number of cancer cells that can be detected in the body after treatment.

Key Dates

Start date
Mar 28, 2024
Status verified
Apr 2026
Primary completion
Mar 28, 2029
Completion
Mar 28, 2029

Study Design

Enrollment
57 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Cohort B
    Men presenting with clinically localized or locoregional high-risk disease.
  • Experimental: Cohort C
    Men presenting with low-volume metastatic disease for whom a multimodality therapeutic approach including removal of the primary has the potential to eliminate all disease.

Primary Outcome Measure

Number of participants with a complete response or minimal residual disease. [ Time Frame: 24 months ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)Basking RidgeNew Jersey07920
Matthew Dallos, MD
646-888-4716
Memorial Sloan Kettering Monmouth (Limited protocol activities)MiddletownNew Jersey07748
Matthew Dallos, MD
646-888-4716
Memorial Sloan Kettering Bergen (Limited Protocol Activities)MontvaleNew Jersey07645
Matthew Dallos, MD
646-888-4716
Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity)CommackNew York11725
Matthew Dallos, MD
646-888-4716
Memorial Sloan Kettering Westchester (Limited Protocol Activities)HarrisonNew York10604
Matthew Dallos, MD
646-888-4716
Memorial Sloan Kettering Cancer Center (All protocol activites)New YorkNew York10065
Matthew Dallos, MD
646-888-4716
Memorial Sloan Kettering Nassau (Limited Protocol Activites)Rockville CentreNew York11553
Matthew Dallos, MD
646-888-4716

Find similar trials in Basking Ridge, NJ

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (Limited protocol activities)· Middletown, NJMemorial Sloan Kettering Bergen (Limited Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk-Commack (Limited protocol activity)· Commack, NYMemorial Sloan Kettering Westchester (Limited Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All protocol activites)· New York, NY

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