NRM on Vascular Perfusion in Healthy Adults

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT06345443
Status
Enrolling By Invitation

Conditions

  • Vascular Stiffness

Eligibility Criteria

Sex
ALL
Age
35 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Nicotinamide Riboside Malate — DIETARY_SUPPLEMENT
    Active supplement.
  • Placebo — OTHER
    Placebo

Study Details

The purpose of this study is to better understand the effects of nicotinamide riboside supplement in overall cardiovascular health in healthy adults.

Key Dates

Start date
Nov 25, 2024
Status verified
Mar 2026
Primary completion
Sep 30, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: 830 mg Nicotinamide and Placebo
    830 mg Nicotinamide supplement capsule and 1 identical Placebo capsule twice a day for 12 weeks
  • Active Comparator: 1660 mg Nicotinamide
    1660 mg Nicotinamide supplement; 2 of the 830 mg capsules twice a day for 12 weeks
  • Placebo Comparator: Placebo
    2 identical Placebo capsules twice a day for 12 weeks

Primary Outcome Measure

Number of Participants with Reduced Endothelial Stiffness [ Time Frame: Baseline to End of study at 12 weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo Clinic in RochesterRochesterMinnesota55905-

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By research site
Mayo Clinic in Rochester· Rochester, MN

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