Tau Biomarkers in Late-onset Psychosis (LOP)

Conditions

• Delusional Disorder (Late Onset)
• Late Onset Schizophrenia

Eligibility Criteria

Sex

ALL

Age

65 Years - 85 Years

Healthy Volunteers

Not accepted

Interventions

• Tau PET imaging scan — DIAGNOSTIC_TEST
  Subjects will be scanned with novel tau PET tracer \[18F\] PI-2620 to determine whether neurofibrillary tangle pathology is present.

Study Details

Hallucinations or delusions that occur for the first time in older people with no acute medical problems or mood symptoms may be related to impending dementia. This study aims to confirm this hypothesis using novel blood biomarkers and Positron Emission Tomography (PET) imaging tracers, as well as non-invasive testing.

Key Dates

Start date

Feb 16, 2024

Status verified

Sep 2025

Primary completion

Dec 31, 2026

Completion

Jun 30, 2027

Study Design

Enrollment

16 participants (estimated)

Primary Outcome Measure

Quantification of neurofibrillary tangle pathology in subjects via PET [18F]PI-2620 radiotracer uptake. [ Time Frame: Each subject will have one PET imaging scan at visit 3 (week 4). ]

Central Contacts

• Nichole Hoehn, MS
  516-562-3492
  [email protected]
• Erica Christen, MS
  516-562-3492
  [email protected]

Locations (1)

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