A Study of Changes in Thinking Related to Aging and Cancer in Breast Cancer Survivors (TRAC)

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06334354
Status
Recruiting
Apply to this trial

Conditions

  • Breast Cancer Survivors

Eligibility Criteria

Sex
FEMALE
Age
60 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Assessments — OTHER
    Sociodemographics, Deficit Accumulation Questionnaires, Remote Cognitive Assessment, Deficit Accumulation Questionnaires,Remote Cognitive Assessment
  • Assessment (Survivors Only) — OTHER
    \*Tumor/Treatment Variables (Survivors Only)
  • APOE and DNA Isolation — OTHER
    Biospecimens procurement and processing

Study Details

The purpose of this study is to look at how differences in cognitive (mental) function develop over time in breast cancer survivors compared to volunteers without a history of cancer (healthy volunteers). Both cancer survivors and healthy volunteers (who are the same age as the cancer survivors) will participate in this study so the researchers can compare the results of neurocognitive testing (which looks at memory, attention, and information processing) on each group of participants.

Key Dates

Start date
May 10, 2024
Status verified
May 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
420 participants (estimated)

Arms

  • Arm: Breast Cancer Survivor (BCS)
    Enrolled participants will be asked to complete a one-time, remote neurocognitive assessment. The neurocognitive assessment will consist of the CogSuite Neurocognitive Battery, an online, remotely deliverable battery of cognitive experimental measures, and a standard battery of remote neuropsychological measures. DNA will be collected via mailed saliva kits to assess Apolipoprotein E (APOE) status.
  • Arm: Non-cancer Control (NCC)
    Enrolled participants will be asked to complete a one-time, remote neurocognitive assessment. The neurocognitive assessment will consist of the CogSuite Neurocognitive Battery, an online, remotely deliverable battery of cognitive experimental measures, and a standard battery of remote neuropsychological measures. DNA will be collected via mailed saliva kits to assess Apolipoprotein E (APOE) status.

Primary Outcome Measure

examine cognitive effects [ Time Frame: within 45 days of participant consent ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)Basking RidgeNew Jersey07920
James Root, PhD
646-888-0035
Memorial Sloan Kettering Monmouth (All protocol activities)MiddletownNew Jersey07748
James Root, PhD
646-888-0035
Memorial Sloan Kettering Bergen (All Protocol Activities)MontvaleNew Jersey07645
James Root, PhD
646-888-0035
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)CommackNew York11725
James Root, PhD
646-888-0035
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604
James Root, PhD
646-888-0035
Memorial Sloan Kettering Cancer CenterNew YorkNew York10065
James Root, PhD
646-888-0035
Denise Correa, PhD
212-610-0491
James Root, PhD (PRINCIPAL_INVESTIGATOR)
Memorial Sloan Kettering Nassau (All Protocol Activities)UniondaleNew York11553
James Root, PhD
646-888-0035

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Memorial Sloan Kettering Basking Ridge (All Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All protocol activities)· Middletown, NJMemorial Sloan Kettering Bergen (All Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk - Commack (All Protocol Activities)· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center· New York, NY

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