Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

Part of paid clinical trials in Lebanon, New Hampshire.

Sponsor
Dartmouth-Hitchcock Medical Center
Study ID
NCT06330545
Status
Recruiting
Apply to this trial

Conditions

  • Dupuytren Contracture

Eligibility Criteria

Sex
ALL
Age
45 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Radiation therapy — RADIATION
    Patients with Dupuytren's Contacture will undergo Collagenase Clostridium Histolyticum injection and release followed by two 5-day courses of radiation therapy separated by 6-8 weeks. They will then be followed for 3 years for recurrence.

Study Details

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

Key Dates

Start date
Sep 16, 2024
Status verified
Nov 2024
Primary completion
Apr 30, 2029
Completion
Apr 30, 2032

Study Design

Enrollment
95 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION

Arms

  • Experimental: Patients with Dupuytren's Contacture
    Patients with Dupuytren's Contacture will undergo Collagenase Clostridium Histolyticum injection and release followed by two 5-day courses of radiation therapy separated by 6-8 weeks. They will then be followed for 3 years for recurrence.

Primary Outcome Measure

Recurrence of Dupuytren's Contracture [ Time Frame: one month, 6 months, 12 months, 24 months, and 36 months post-radiation treatment ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Dartmouth HitchcockLebanonNew Hampshire03766
Julia Schwarz, MD
[email protected]
6036505133

Find similar trials in Lebanon, NH

By research site
Dartmouth Hitchcock· Lebanon, NH

Related Studies