AI Derived Biomarker to Select Neoadjuvant Treatment for Borderline Resectable Pancreatic Ductal Adenocarcinoma

Part of paid clinical trials in Buffalo, New York.

Sponsor
Roswell Park Cancer Institute
Study ID
NCT06320717
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Blood sample — OTHER
    To determine if there are any biomarkers in the blood that could be used to choose best treatment plan for future patients

Study Details

To collect samples and information from patients who will be undergoing standard of care neoadjuvant treatment with either FOLFIRINOX or Gemcitabine + Nab-paclitaxel. The information collected will be used to determine if there are any "biomarkers" in your blood or tumor tissue that, when compared to your response to the neoadjuvant treatment, could be used to choose the best treatment option for future patients with similar biomarkers.

Key Dates

Start date
Jan 2, 2024
Status verified
Apr 2026
Primary completion
Jul 2, 2026
Completion
Jul 2, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Patients with Borderline Resectable (Cohort A)
    Pathological response of Patients with borderline resectable disease (per NCCD Criteria) treated with standard care chemotherapy
  • Arm: Patients with Resectable (Cohort B)
    Pathological response of Patients with resectable disease (per NCCN criteria) treated with standard care chemotherapy

Primary Outcome Measure

Retrospective prediction of pCR in resectable patients [ Time Frame: Up to 2 years ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Roswell Park Comprehensive Cancer CenterBuffaloNew York14263-
Good Samaritan University HospitalWest IslipNew York11795
John Loscalzo, MD
631-417-8600
John Loscalzo, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Buffalo, NY

By condition
Pancreatic cancer
By specialty
OncologyGI oncology
By research site
Roswell Park Comprehensive Cancer Center· Buffalo, NYGood Samaritan University Hospital· West Islip, NY

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