Self-Adhering Magnetic Device to Treat Corneal Exposure

Conditions

• Corneal Exposure
• Paralytic Lagophthalmos

Eligibility Criteria

Sex

ALL

Age

18 Years - 80 Years

Healthy Volunteers

Not accepted

Interventions

• temporary magnetic system for tarsorrhaphy (MST) — DEVICE
  cutting-edge technology has produced smaller magnets with stronger magnetic fields, prompting experts to revisit the use of magnets to facilitate eyelid closure

Study Details

Paralytic lagophthalmos can be difficult to treat and manage. It has a host of causes and effects, one of which (for the latter) is exposure keratopathy. Untreated, this can lead to corneal ulceration, inflammation, and potentially blindness. Despite a variety of attempts at treating this complex condition, none have satisfactorily reduced complications ranging from ease of use to aesthetics. With improvement in magnetic technology, however, that may change. Barmettler et al (2014) have demonstrated preliminary success of externally affixed magnets in closing both model and patient eyelids. As such, we hypothesize that magnetic devices can be used to treat corneal exposure by controlling eyelid position.

Key Dates

Start date

Apr 17, 2024

Status verified

May 2026

Primary completion

Sep 1, 2027

Completion

Sep 1, 2027

Study Design

Enrollment

25 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Arms

• Other: Assess the performance of this novel eyelid closure device in vivo
  The primary goal of this study is to determine the feasibility and success of a temporary magnetic system for tarsorrhaphy (MST) to provide adequate closure of the eyes for ultimate use in conditions causing lagophthalmos (a disorder in eyelid closure). In this disorder, people are unable to sufficiently cover their cornea (the front of the eye), which can lead to dryness, infection, scarring and even blindness. Current therapies are invasive, involving local anesthesia and surgeries, and have a negative cosmetic impact.

Primary Outcome Measure

Number of participants with success of a temporary magnetic system for tarsorrhaphy [ Time Frame: through study completion, an average of 3 years ]

Central Contacts

• Van Ann Tran, MD
  312-996-9120
  [email protected]

Locations (1)

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