Outcomes of Running Locking Suture vs Standard Running Suture in Surgical Wounds

Part of paid clinical trials in Sacramento, California.

Sponsor
University of California, Davis
Study ID
NCT06288009
Status
Recruiting
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Conditions

  • Scarring

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Running locking suture — PROCEDURE
    In running locking sutures, the first anchoring knot is made at one end of the wound, and a loop of suture is left from the beginning of the throw. The needle is then passed through the loop of suture, locking the suture in place. This is repeated until reaching the end of the wound, where the suture material is then tied to the loop using an instrument tie for the final throw.
  • Standard running suture — PROCEDURE
    In standard running sutures, the first anchoring knot is made at one end of the wound, and all of the suture material is pulled through after completing the throw. This is repeated until reaching the end of the wound, where the suture material is then tied.

Study Details

When patients have surgery on the head and face, stitches are the standard way to close the wound. Wounds always result in a scar, but doctors are always looking for ways to reduce scarring. Several studies have been done to test ways to close wounds that reduce scarring. The most commonly performed closure technique uses running sutures, where a single strand of suture is continued along the length of the wound with a series of uninterrupted stiches. However, alternative closure techniques exist such as the running locking suture, which can offer advantages such as improved tension and thus reduce post-operative complications with better aesthetic outcome. In this study, half the wound will be stitched with standard running sutures and the other half will be stitched with running locking sutures. This will allow us to see if the side with running locking sutures heals with less scarring.

Key Dates

Start date
Aug 1, 2024
Status verified
Dec 2025
Primary completion
Aug 1, 2026
Completion
Oct 1, 2026

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Layered Closure with Running Locking Suture on Side A
    For all participants, one wound side half will be labeled as A and the other side as B. The bottom (subcutaneous) layer of the entire wound will receive the normal stitching. For the upper (cutaneous) layer, Side A will be closed with a running locking suture, and Side B will be closed with a standard running suture.
  • Experimental: Layered Closure with Running Locking Suture on Side B
    For all participants, one wound side half will be labeled as A and the other side as B. The bottom (subcutaneous) layer of the entire wound will receive the normal stitching. For the upper (cutaneous) layer, Side B will be closed with a running locking suture, and Side A will be closed with a standard running suture.

Primary Outcome Measure

Observer Scar Assessment as measured by Patient Observer Scar Assessment Score (POSAS) [ Time Frame: 3 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Davis - Dermatology DepartmentSacramentoCalifornia95816
John Robb, BS
[email protected]
916-551-2636
Daniel Eisen, MD
[email protected]
916-551-2611
Daniel Eisen, MD (PRINCIPAL_INVESTIGATOR)
Keemberly Kim, MD (SUB_INVESTIGATOR)
Samantha Daniel, MD (SUB_INVESTIGATOR)

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By research site
University of California, Davis - Dermatology Department· Sacramento, CA

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