Oxytocin Rest to Reduce Cesarean Delivery

Part of paid clinical trials in Newark, Delaware.

Sponsor
Christiana Care Health Services
Study ID
NCT06268431
Status
Recruiting
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Conditions

  • Failed Induction
  • Labor Dystocia
  • Prolonged Labor

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 55 Years
Healthy Volunteers
Not accepted

Interventions

  • Oxytocin rest — OTHER
    60-minute oxytocin rest

Study Details

Prolonged labor is usually managed with continuous oxytocin infusion. "Oxytocin rest" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. "Oxytocin rest" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice. The purpose of this study is to assess whether oxytocin rest of 60 minutes in patients with prolonged labor reduces risk for cesarean delivery.

Key Dates

Start date
Mar 19, 2024
Status verified
Oct 2024
Primary completion
Feb 15, 2026
Completion
Mar 15, 2026

Study Design

Enrollment
350 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: 60-minute oxytocin rest
  • No Intervention: Usual care with continuous oxytocin infusion

Primary Outcome Measure

Cesarean rate [ Time Frame: At time of delivery ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
ChristianaCare Health SystemNewarkDelaware19718
Teresa C Logue
[email protected]
302-733-6563

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By research site
ChristianaCare Health System· Newark, DE

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