Distinguishing Alcohol Intoxication, Cannabis Intoxication and Co-intoxication Using Electroencephalography (EEG)

Part of paid clinical trials in Fort Collins, Colorado.

Sponsor
Colorado State University
Study ID
NCT06259916
Status
Recruiting
Apply to this trial

Conditions

  • Alcohol Use, Unspecified
  • Cannabis Use

Eligibility Criteria

Sex
ALL
Age
21 Years - 50 Years
Healthy Volunteers
Accepted

Interventions

  • Alcohol — OTHER
    Participants in this condition will receive the standard alcohol dose
  • Cannabis — OTHER
    Participants in this group will self-administer legal-market flower cannabis

Study Details

This is a randomized, parallel-group study designed to explore the differences between cannabis intoxication, alcohol intoxication and co-intoxication involving both alcohol and cannabis, utilizing electroencephalography (EEG) as well as more traditional intoxication measures such as breath alcohol concentration and balance metrics. If eligible for the study, participants will be randomized to complete one study session in our mobile laboratory, during which they will use either alcohol, cannabis (which will be self-administered, ad libitum) or both alcohol and cannabis.

Key Dates

Start date
Jan 5, 2024
Status verified
Nov 2025
Primary completion
May 30, 2026
Completion
May 30, 2026

Study Design

Enrollment
99 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Experimental: Cannabis Group
    Participants in this group will self-administer their own flower cannabis product (that they purchased for use in the study from a legal-market dispensary) ad libitum inside their homes. Researchers will not handle the product or instruct participants on how much to use during the session.
  • Experimental: Alcohol Group
    Participants in this group will be administered a dose of alcohol by researchers in our mobile lab. The dose is designed (based on participant sex and body weight) to bring blood alcohol concentration to .06 g/dL.
  • Experimental: Alcohol + Cannabis Group
    Participants in this group will first self-administer their own flower cannabis product (that they purchased for use in the study from a legal-market dispensary) ad libitum inside their homes. Researchers will not handle the product or instruct participants on how much to use during the session. They will then return to the mobile lab which will be parked outside their residence and will be administered a dose of alcohol by researchers. The dose is designed (based on participant sex and body weight) to bring blood alcohol concentration to .06 g/dL.

Primary Outcome Measure

Electroencephalography (EEG) Objective Cognitive Function Measures--Amplitude (microvolts) [ Time Frame: Immediately pre-substance use, 1-hour post-use, 2-hours post-use, 4-hours post-use ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Colorado State UniversityFort CollinsColorado80523
Hollis C. Karoly, PhD
Hollis C. Karoly, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Fort Collins, CO

By research site
Colorado State University· Fort Collins, CO

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