rTMS Over the Dorsolateral Prefrontal Cortex for the Treatment of Impulse Control Disorders in Parkinson's Disease

Part of paid clinical trials in Morgantown, West Virginia.

Sponsor
West Virginia University
Study ID
NCT06237868
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • rTMS Active — DEVICE
    The participants undergo Active rTMS, approximately 10-15 min and then complete tasks and questionnaires.
  • rTMS Sham — DEVICE
    The participants undergo Sham rTMS, approximately 10-15 min and then complete tasks and questionnaires.

Study Details

This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.

Key Dates

Start date
May 1, 2024
Status verified
Apr 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: rTMS Active
    the participant will receive a type of TMS called repetitive TMS (rTMS) wherein the magnetic pulses delivered will be close together in a rapid sequence over the dlPFC. Participants receive excitatory rTMS with a stimulation frequency of 20 Hz between 100-120% of their resting motor threshold.
  • Sham Comparator: rTMS Sham
    Sham rTMS will be the same as real rTMS, except a special sham coil will be used, which produces the same sensation on the scalp of the patients as the real coil but delivers no magnetic stimulation to the brain.

Primary Outcome Measure

Change in Delay-Discounting [ Time Frame: Baseline to 1 hour following the intervention ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
West Virginia University HospitalsMorgantownWest Virginia26505
Mariya V Cherkasova, PhD
[email protected]
2403673068

Find similar trials in Morgantown, WV

By condition
Parkinson's disease
By specialty
NeurologyBrain disorders
By research site
West Virginia University Hospitals· Morgantown, WV

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