Reducing the Risk of Chronic Hypertension and Improving Vascular Function Following Preeclampsia

Conditions

• Hypertension, Pregnancy-Induced

Eligibility Criteria

Sex

FEMALE

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Nifedipine ER — DRUG
  Initiation of nifedipine ER postpartum at randomly assigned threshold during the first 6 weeks postpartum.

Study Details

The long-term goal of our work is to evaluate the effect of intensive postpartum blood pressure control on maternal cardiovascular health, risk of chronic hypertension, and reversal of vascular dysfunction generated by hypertensive disorders of pregnancy, thus attenuating the lifelong trajectory of cardiovascular disease risk.

Key Dates

Start date

Oct 23, 2024

Status verified

May 2025

Primary completion

Mar 31, 2029

Completion

Jun 30, 2029

Study Design

Enrollment

618 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Experimental: REPAIR ARM
  Intensive postpartum blood pressure control with nifedipine ER initiation at systolic blood pressure (SBP) ≥140 mmHg or diastolic blood pressure (DBP) ≥90 mmHg and maintaining blood pressure \<140/90 mmHg during the first 6 weeks postpartum.
• Active Comparator: CONTROL ARM
  Usual care with nifedipine ER initiation at SBP ≥150 mmHg or DBP ≥100 mmHg and maintaining blood pressure \<150/100 mmHg during the first 6 weeks postpartum.

Primary Outcome Measure

Chronic hypertension [ Time Frame: One year postpartum ]

Central Contacts

• Alyssa M Hernandez, DO
  4148055285
  [email protected]
• Amandla Stanley, MSN
  4148056691
  [email protected]

Locations (2)

Find similar trials in Chicago, IL

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