A Computerized Depression Intervention in Veterans

Part of paid clinical trials in Waco, Texas.

Sponsor
VA Office of Research and Development
Study ID
NCT06217198
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Deprexis — BEHAVIORAL
    Deprexis is an internet-delivered treatment for depressive symptoms and related functional impairment. The intervention draws from various theoretical frameworks and consists of 12 modules: 10 core content modules and an introductory and summary module. Deprexis is designed to be interactive, includes answering questions and learning techniques and concepts through instruction and examples.

Study Details

Depressive symptoms are common among Veterans and associated with significant impairment. Timely intervention has the potential to improve mental health outcomes and restore functioning. Interventions delivered through the internet can be completed remotely at any time, and thus minimize burden on Veterans, however the research examining their utility in Veterans is limited. This proposed project will examine Deprexis, a self-guided internet-delivered intervention, which targets depressive symptoms and associated functional impairments. Interviews will be conducted to gain insight into Veterans' perceptions, needs, and preferences vis-a-vis Deprexis, with results informing a randomized controlled trial. Here an 8-week course of Deprexis will be compared to a treatment-as-usual (TAU) control condition to establish if Deprexis is acceptable and effective for Veterans with mild to moderate depressive symptoms. Veterans engaged in Deprexis are hypothesized to show improvements on measures of functioning and decreases in depressive symptoms compared to the TAU control group. The proposed work has great clinical utility, as it could provide a readily accessible, high-quality intervention for the many Veterans suffering from depressive symptoms, with the potential to improve functioning and long-term outcomes.

Key Dates

Start date
May 1, 2024
Status verified
Jul 2025
Primary completion
Apr 30, 2029
Completion
Apr 30, 2029

Study Design

Enrollment
152 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Deprexis
    Deprexis: an internet-delivered psychosocial treatment for depressive symptoms and related functional impairment.
  • No Intervention: Treatment-as-Usual
    Access to standard non-study care

Primary Outcome Measure

Quick Inventory of Depressive Symptomatology (Self-Report; QIDS-SR-16) Change [ Time Frame: Baseline, Post-Treatment (week 8), Follow-up (week 16) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TXWacoTexas76711
David E Dostal, PhD MA BS
[email protected]
254-743-2464
Lance Starzyk, BAAS AA
[email protected]
(254) 743-2409
Rahel R Pearson, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Waco, TX

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX· Waco, TX

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