Escitalopram in Asthma Patients With Frequent Exacerbation

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT06216535
Phase
PHASE2
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Escitalopram — DRUG
    Escitalopram is an FDA-approved SSRI antidepressant that is administered by mouth
  • Placebo — DRUG
    Inactive placebo comparator

Study Details

Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), such as escitalopram are widely used for mood and anxiety disorders. However, they have also been explored, with promising findings, for a variety of disorders outside of psychiatry. Clinical studies of SSRIs in depressed people with asthma were associated with decreased asthma exacerbations and improvement in asthma control. In this study, the number of asthma exacerbations will be assessed as the primary outcome measure in patients using escitalopram vs. placebo.

Key Dates

Start date
May 19, 2025
Status verified
Jan 2026
Primary completion
Dec 1, 2028
Completion
Jun 1, 2029

Study Design

Enrollment
105 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Placebo Comparator: Placebo
    Participants will receive an inactive placebo by mouth using the same administration schedule as for escitalopram.
  • Active Comparator: Escitalopram
    Participants will take oral escitalopram 10 mg per day for two weeks, followed by oral escitalopram 20 mg per day for 22 weeks. Participants will take oral escitalopram 10 mg per day for one week at the final study visit.

Primary Outcome Measure

Total number of severe asthma exacerbations [ Time Frame: 24 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UT Southwestern, 1440 Empire Central, Ste. LD4.100DallasTexas75247
Reagan Volzer, MS
[email protected]
214-645-6963
Génesis González Álvarez, MS
[email protected]
214-645-6967
Sherwood Brown, M.D, Ph.D (PRINCIPAL_INVESTIGATOR)

Find similar trials in Dallas, TX

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
UT Southwestern, 1440 Empire Central, Ste. LD4.100· Dallas, TX

Related Studies