A Study to Evaluate the Long-Term Safety and Efficacy of Povorcitinib in Participants With Moderate to Severe Hidradenitis Suppurativa

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Incyte Corporation
Study ID
NCT06212999
Phase
PHASE3
Status
Active Not Recruiting

Conditions

  • Hidradenitis Suppurativa (HS)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The purpose of this study is to evaluate long-term safety and efficacy of povorcitinib in participants with moderate to severe hidradenitis suppurativa who completed the 54 weeks of study treatment within the originating parent Phase 3 studies (INCB 54707-301 \[NCT05620823\] or INCB 54707-302 \[NCT05620836\]).

Key Dates

Start date
Jan 30, 2024
Status verified
Mar 2026
Primary completion
Dec 26, 2026
Completion
Dec 26, 2026

Study Design

Enrollment
617 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Cohort A
    Povorcitinib at the protocol-defined dose strength based on cohort assignment.
  • Experimental: Cohort B
    Povorcitinib at the protocol-defined dose strength based on cohort assignment.
  • Experimental: Cohort C
    Povorcitinib at the protocol-defined dose strength based on cohort assignment.

Primary Outcome Measure

Proportion of participants with Treatment-Emergent Adverse Events (TEAEs) [ Time Frame: up to approximately 56 weeks ]

Locations (61)

FacilityCityStateZIPSite coordinators
Investigative Site US303PhoenixArizona85006-
Investigative Site US240ScottsdaleArizona85255-
Investigative Site US307Fort SmithArkansas72916-
Investigative Site US214RogersArkansas72758-
Investigative Site US315Laguna NiguelCalifornia92677-
Investigative Site US223Los AngelesCalifornia90033-
Investigative Site US222OaklandCalifornia94611-
Investigative Site US226San DiegoCalifornia92103-
Investigative Site US309ClearwaterFlorida33614-
Investigative Site US317HialeahFlorida33012-3618-
Investigative Site US306HollywoodFlorida33021-
Investigative Site US320HollywoodFlorida33021-
Investigative Site US316MaitlandFlorida32751-
Investigative Site US227MargateFlorida33063-
Investigative Site US204MiamiFlorida33125-
Investigative Site US236MiamiFlorida33173-
Investigative Site US321North Miami BeachFlorida33162-4708-
Investigative Site US200OcalaFlorida34470-
Investigative Site US201TampaFlorida33613-
Investigative Site US228TampaFlorida33609-
Investigative Site US311MariettaGeorgia30060-
Investigative Site US220West DundeeIllinois60118-
Investigative Site US206IndianapolisIndiana46250-
Investigative Site US337IndianapolisIndiana46250-
Investigative Site US341Bowling GreenKentucky42104-
Investigative Site US209LouisvilleKentucky40241-
Investigative Site US305Baton RougeLouisiana70809-
Investigative Site US207MetairieLouisiana70006-
Investigative Site US229New OrleansLouisiana70115-
Investigative Site US224BaltimoreMaryland21287-
Investigative Site US325MarriottsvilleMaryland21104-
Investigative Site US225BostonMassachusetts02115-
Investigative Site US304BostonMassachusetts02215-
Investigative Site US310BrightonMassachusetts02135-
Investigative Site US221QuincyMassachusetts02169-
Investigative Site US213Fort GratiotMichigan48059-
Investigative Site US217WaterfordMichigan48328-
Investigative Site US212MinneapolisMinnesota55455-
Investigative Site US302St LouisMissouri63110-
Investigative Site US318PortsmouthNew Hampshire03801-
Investigative Site US230East WindsorNew Jersey08520-
Investigative Site US324Kew GardensNew York11415-
Investigative Site US202New YorkNew York10028-
Investigative Site US210RochesterNew York14620-
Investigative Site US205Chapel HillNorth Carolina27516-
Investigative Site US215BexleyOhio43209-
Investigative Site US339BexleyOhio43209-
Investigative Site US330BoardmanOhio44512-
Investigative Site US314CincinnatiOhio45219-
Investigative Site US312ClevelandOhio44106-
Investigative Site US203GahannaOhio43230-
Investigative Site US301PortlandOregon97201-
Investigative Site US232MurfreesboroTennessee37130-
Investigative Site US235ArlingtonTexas76011-
Investigative Site US218BellaireTexas77401-
Investigative Site US340BellaireTexas77401-
Investigative Site US238PflugervilleTexas78660-
Investigative Site US300PlanoTexas75025-
Investigative Site US234San AntonioTexas78213-
Investigative Site US313NorfolkVirginia23502-
Investigative Site US308SpokaneWashington99202-

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