EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation

Part of paid clinical trials in Richmond, Virginia.

Sponsor
Virginia Commonwealth University
Study ID
NCT06212791
Status
Recruiting
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Conditions

  • Paroxysmal Atrial Fibrillation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Self- Report Evaluation-Duke Activity Status Index — BEHAVIORAL
    Complete the Self- Report Evaluation-Duke Activity Status Index
  • Self- Report Evaluation Atrial Fibrillation Effect on Quality of Life Questionnaire — BEHAVIORAL
    Complete the Self- Report Evaluation, Atrial Fibrillation Effect on Quality of Life Questionnaire
  • Cardiopulmonary exercise test (CPET) — DIAGNOSTIC_TEST
    Cardiopulmonary exercise test (CPET)
  • Transthoracic echocardiogram — DIAGNOSTIC_TEST
    Transthoracic echocardiogram at rest and immediately following peak exercise during CPET
  • Ambulatory cardiac rhythm assessment — DIAGNOSTIC_TEST
    Ambulatory cardiac rhythm assessment
  • Cardiovascular magnetic resonance (CMR) — DIAGNOSTIC_TEST
    Cardiovascular magnetic resonance (CMR) study at rest and during two stages of submaximal exercise (ExeCMR)

Study Details

Longitudinal, observational cohort study to evaluate changes in left atrial (LA) reservoir function during exercise and overall exertional capacity in patients following catheter ablation for paroxysmal atrial fibrillation (AF).

Key Dates

Start date
Dec 26, 2024
Status verified
Mar 2026
Primary completion
Mar 31, 2028
Completion
Mar 31, 2028

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Patients under going catheter ablation
    Patients undergoing catheter ablation for paroxysmal AF, reduction or elimination of arrhythmia burden

Primary Outcome Measure

Change in LA reservoir function reserve at submaximal exercise after catheter ablation in patients with paroxysmal AF. [ Time Frame: Baseline and the follow up testing will be performed 5-6 months (to be more specific: 150-180 days) after catheter ablation. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Virginia Commonwealth UniversityRichmondVirginia23298
Pamela Grizzard
[email protected]
804-628-6234
Melissa Sears
[email protected]
804-828-1601

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Virginia Commonwealth University· Richmond, VA

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