Effects of Movement Retraining on Knee Loading in Individuals With Knee Osteoarthritis

Part of paid clinical trials in Stanford, California.

Sponsor
Stanford University
Study ID
NCT06208631
Status
Recruiting
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Conditions

  • Osteoarthritis, Knee

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Gait retraining — BEHAVIORAL
    Changing muscle coordination while walking

Study Details

This study investigates how well individuals with knee osteoarthritis can learn to alter their calf muscle activation using haptic biofeedback while walking and evaluates how these changes affect knee loading. Prior research has utilized musculoskeletal simulations to determine that reducing the activation of one of the calf muscles, the gastrocnemius, can have a large impact on reducing knee loading. However, this has not been tested in individuals with knee osteoarthritis. In this study, participants will be trained to alter the activation of their gastrocnemius muscle, by receiving haptic feedback after each step. The feedback will indicate how the participant changed their muscle activation relative to baseline. Some participants will train on a treadmill in the laboratory for up to two sessions, with 30 minutes of walking with feedback in each session. If a participant can learn to adjust their muscle activation in the first training session, they will be able to complete the second training session. Other participants will train outside the laboratory for one session with 30 minutes of walking with feedback to investigate changes in knee loading while using the new walking strategy during over-ground walking. The movement data collected during the training sessions will be used as inputs to computer simulations of the musculoskeletal system to determine if walking with the new muscle activation strategy reduces knee loading.

Key Dates

Start date
Jan 18, 2024
Status verified
Oct 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
31 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Experimental: Gait modification
    Participants will learn to change muscle coordination while walking through real-time haptic biofeedback based on the activation of the gastrocnemius muscle

Primary Outcome Measure

Change from baseline in knee contact force [ Time Frame: Evaluated during the 30 minutes of feedback walking in the second in-lab session and out-of-lab session ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford Human Performance LabStanfordCalifornia94305
Scott D Uhlrich, PhD
[email protected]
650-721-2547

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Stanford Human Performance Lab· Stanford, CA

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