A Study of Orforglipron (LY3502970) Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin

Part of paid clinical trials in Canoga Park, California.

Sponsor
Eli Lilly and Company
Study ID
NCT06192108
Phase
PHASE3
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The main purpose of this study is to assess the safety and efficacy of orforglipron compared with dapagliflozin in improving blood sugar control in participants with type 2 diabetes (T2D) with inadequate glycemic control using metformin. The study will last approximately 46 weeks.

Key Dates

Start date
Jan 10, 2024
Status verified
Oct 2025
Primary completion
Sep 26, 2025
Completion
Sep 26, 2025

Study Design

Enrollment
962 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Orforglipron Dose 1
    Participants will receive orforglipron orally.
  • Experimental: Orforglipron Dose 2
    Participants will receive orforglipron orally.
  • Experimental: Orforglipron Dose 3
    Participants will receive orforglipron orally.
  • Active Comparator: Dapagliflozin
    Participants will receive dapagliflozin orally.

Primary Outcome Measure

Change from Baseline in Hemoglobin A1c: (HbA1c) [ Time Frame: Baseline, Week 40 ]

Locations (19)

FacilityCityStateZIPSite coordinators
Alliance Research Institute - Canoga ParkCanoga ParkCalifornia91304-
Ark Clinical ResearchLong BeachCalifornia90815-
Collaborative Neuroscience Research, LLCLos AlamitosCalifornia90720-
Wolverine Clinical TrialsSanta AnaCalifornia92706-
CMR of Greater New Haven, LLCHamdenConnecticut06517-
Institute of Endocrinology Diabetes, Health & HormoneStockbridgeGeorgia30281-
Elite Clinical TrialsRexburgIdaho83440-
Accellacare - DuPageLombardIllinois60148-
Tandem Clinical ResearchMarreroLouisiana70072-
St. Vincent HealthcareBillingsMontana59101-
Albuquerque Clinical Trials, Inc.AlbuquerqueNew Mexico87102-
Accellacare - Winston-SalemWinston-SalemNorth Carolina27103-
Alliance for Multispecialty Research, LLCNormanOklahoma73069-
Essential Medical ResearchTulsaOklahoma74137-
Accellacare - Mt PleasantMt. PleasantSouth Carolina29464-
Accellacare, US Inc., d/b/a Accellacare of KnoxvilleJefferson CityTennessee37760-
Velocity Clinical Research, DallasDallasTexas75230-
Juno ResearchHoustonTexas77040-
Consano Clinical Research, LLCShavano ParkTexas78231-

Related coverage on Hipa.ai

Find similar trials in Canoga Park, CA

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Alliance Research Institute - Canoga Park· Canoga Park, CAArk Clinical Research· Long Beach, CACollaborative Neuroscience Research, LLC· Los Alamitos, CAWolverine Clinical Trials· Santa Ana, CACMR of Greater New Haven, LLC· Hamden, CTInstitute of Endocrinology Diabetes, Health & Hormone· Stockbridge, GA

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