Radiation Induced Alterations in Resting State Brain Networks in Pediatric Brain Tumor Patients

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT06185686
Status
Recruiting
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Conditions

  • Brain Tumor, Primary

Eligibility Criteria

Sex
ALL
Age
8 Years - 21 Years
Healthy Volunteers
Not accepted

Interventions

  • Cognitive testing — OTHER
    NIH Toolbox Cognitive Battery and the Novel Cognitive Measure (NCM)
  • Resting State MRI/Precision functional mapping — DEVICE
    At baseline (before the end of radiation therapy) and approximately 12 months after the completion of radiation therapy.

Study Details

With modern therapy, the survival rate for pediatric brain tumor patients has significantly improved, with over 70% of patients surviving their disease. However, this progress often comes at the cost of substantial morbidity, with cognitive deficits being the primary obstacle to independent living. Robust predictors of cognitive decline and a comprehensive understanding of the underlying mechanisms of cognitive injury remain elusive. This study will prospectively investigate alterations in brain resting state networks following radiation therapy using functional imaging. The hypothesis is that radiation therapy leads to dose-dependent alterations in functional connectivity in the networks associated with higher level cognition, ultimately leading to cognitive decline.

Key Dates

Start date
Jul 10, 2024
Status verified
Jul 2025
Primary completion
Jul 31, 2027
Completion
Jul 31, 2027

Study Design

Enrollment
16 participants (estimated)

Arms

  • Arm: Brain tumor patients receiving proton radiation therapy
    Patients between 8 and 21 years old (inclusive) with a newly diagnosed primary brain tumor that will be treated with proton radiation therapy

Primary Outcome Measure

Radiation induced effects on functional brain resting state connectivity [ Time Frame: Through 1 year follow-up ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of Medicine/Saint Louis Children's HospitalSt LouisMissouri63110
Stephanie Perkins, M.D.
[email protected]
314-747-4405
Stephanie Perkins, M.D. (PRINCIPAL_INVESTIGATOR)
Scott Marek, Ph.D. (SUB_INVESTIGATOR)
Joshua Shimony, M.D., Ph.D. (SUB_INVESTIGATOR)
Margaret Shatara, M.D. (SUB_INVESTIGATOR)

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