Auditory Prediction and Error Evaluation in the Speech of Individuals Who Stutter

Part of paid clinical trials in Tempe, Arizona.

Sponsor
Arizona State University
Study ID
NCT06181149
Status
Recruiting
Apply to this trial

Conditions

  • Healthy Subjects
  • Stuttering, Developmental

Eligibility Criteria

Sex
ALL
Age
3 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Delaying speech initiation — BEHAVIORAL
    This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use transcranial magnetic stimulation to induce a temporal misalignment between prediction and auditory feedback while participants produce speech.
  • Auditory errors and pre-speech auditory modulation — BEHAVIORAL
    This intervention will examine the contributions of auditory errors to pre-speech auditory modulation. Participants will receive auditory perturbations while speaking, and we will collect their brain activities throughout the study.
  • Contributions of the speech premotor cortex to pre-speech auditory modulation — BEHAVIORAL
    This intervention will examine the effects of stimulation of the left ventral premotor cortex on pre-speech auditory modulation. Participants will receive electrical stimulation while speaking.
  • Delaying auditory feedback — BEHAVIORAL
    This intervention will examine the effects of misalignment between prediction and auditory feedback in participants. We will use delayed auditory feedback to induce a temporal misalignment between prediction and auditory feedback while participants produce speech.

Study Details

Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. This study will provide a strong foundation for developing neural and behavioral interventions for stuttering. Participants will be asked to name pictures, read words/sentences silently or aloud, and listen to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation while reading and speaking.

Key Dates

Start date
Jan 1, 2024
Status verified
Aug 2025
Primary completion
Dec 30, 2027
Completion
Dec 30, 2027

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Group 1
  • Experimental: Group 2
  • Experimental: Group 3
  • Experimental: Group 4

Primary Outcome Measure

Change in brain activity before and during speaking [ Time Frame: within each session of the study that may last up to 2 hours ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Arizona State UniversityTempeArizona85287
Ayoub Daliri
[email protected]
480-727-8397
Ayoub Daliri, PhD (PRINCIPAL_INVESTIGATOR)
Univeristy of WashingtonSeattleWashington98105
Ludo Max
[email protected]
206-543-2674
Ludo Max, PhD (PRINCIPAL_INVESTIGATOR)

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