A Study of Niacin Regulation

Conditions

• Excessive Weight Gain

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Accepted

Interventions

• Niacin — DRUG
  Intravenous administration of dose titrated from 10 µg·kg FFM-1·min-1 to 30 µg·kg for approximately 4.5 hours on one occasion

Study Details

Adults who gain most of their excess weight in the abdominal area typically do not respond to things that "turn off" fat cells the same way as lean people. The researchers are trying to understand why fat tissue responds differently in people with different body types.

Key Dates

Start date

Jan 1, 2024

Status verified

Apr 2026

Primary completion

May 31, 2027

Completion

May 31, 2027

Study Design

Enrollment

32 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Upper body obesity
  Subjects identify with upper body obesity will receive Niacin to lean how fat cells in different regions of the body the response.
• Experimental: Normal weight
  Subjects identify with normal body weight will receive Niacin to lean how fat cells in different regions of the body the response.

Primary Outcome Measure

Change in plasma free fatty acid (FFA) concentrations [ Time Frame: Baseline, post treatment (approximately 4 hours) ]

Central Contacts

• Pamela Reich
  507-255-6062
  [email protected]
• Kelli Lytle, PhD
  [email protected]

Locations (1)

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