MMRC Horizon One: RRMM (MMRC-099)

Part of paid clinical trials in Duarte, California.

Sponsor
Multiple Myeloma Research Consortium
Study ID
NCT06171685
Phase
PHASE2
Status
Active Not Recruiting

Conditions

  • Refractory Multiple Myeloma
  • Relapse Multiple Myeloma

Eligibility Criteria

Sex
ALL
Age
18 Years - 99 Years
Healthy Volunteers
Not accepted

Interventions

Study Details

This trial is an adaptive platform trial. The structure of the protocol allows the trial to evolve over time. Multiple investigational arms will be included within the trial under a Master Protocol (MP). These investigational arms may be added as appendices at different times depending on whether they are trial-ready and whether accrual in the trial will support another arm. Accrual to an arm will terminate in accord with the arm's appendix to the Master Protocol. The purpose of this proposed structure is to support the recurrent research challenge of efficiently evaluating what is the best therapy for a particular patient.

Key Dates

Start date
Nov 17, 2024
Status verified
Jun 2026
Primary completion
Jul 31, 2029
Completion
Jul 31, 2030

Study Design

Enrollment
300 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Sub-protocol A
    Serves as the reference arm for the platform
  • Experimental: Sub-Protocol B
    This arm will be an investigational arm

Primary Outcome Measure

ORR [ Time Frame: through completion of the study, and yearly ]

Locations (13)

FacilityCityStateZIPSite coordinators
City of HopeDuarteCalifornia91010-
Emory Winship Cancer CenterAtlantaGeorgia30322-
University of Chicago Cancer CenterChicagoIllinois60637-
Beth Israel Deaconess Medical CenterBostonMassachusetts02215-
Dana Farber Cancer Institute/Harvard Medical SchoolBostonMassachusetts02215-
Barbara Ann Karmanos Cancer CenterDetroitMichigan48201-
Mayo Clinic RochesterRochesterMinnesota55905-
Washington University MedicineSt LouisMissouri63110-
Hackensack University Medical CenterHackensackNew Jersey07601-
Memorial Sloan Kettering Cancer CenterNew YorkNew York10022-
Mt. Sinai School of MedicineNew YorkNew York10029-
Atrium Levine Cancer InstituteCharlotteNorth Carolina28203-
Tennessee OncologyNashvilleTennessee37203-

Find similar trials in Duarte, CA

By research site
City of Hope· Duarte, CAEmory Winship Cancer Center· Atlanta, GAUniversity of Chicago Cancer Center· Chicago, ILBeth Israel Deaconess Medical Center· Boston, MADana Farber Cancer Institute/Harvard Medical School· Boston, MABarbara Ann Karmanos Cancer Center· Detroit, MI

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