Laryngeal and Vocal Tract Strategies to Reduce Vocal Fold Contact Pressure

Conditions

• Mid-membranous Vocal Fold Lesion

Eligibility Criteria

Sex

ALL

Age

18 Years - 40 Years

Healthy Volunteers

Not accepted

Interventions

• Resonant voice therapy — BEHAVIORAL
  Resonant voice therapy is a standard of care procedure for treating phonotraumatic vocal hyperfunction. The full standardized voice therapy program will have a duration of four weeks, each week with one 60-minute therapy session.

Study Details

Phonotraumatic vocal hyperfunction is one of the most frequently occurring conditions to affect the voice. This voice disorder often involves vocal fold injury due to repeated, excessive contact pressure between the vocal folds when they collide during voice production. In the clinic, voice therapy attempts to modify unhealthy vocal behaviors through different techniques or exercises. While voice therapy is generally considered effective, the scientific rationale for its therapeutic benefits still remains unclear. It is generally believed that these exercises lead to adjustments in the larynx and vocal tract that reduce vocal fold contact pressure. However, this assumption has never been tested in humans or laboratory experiments. The goal of this clinical trial is to investigate the effectiveness of voice therapy in reducing vocal fold contact pressures and in eliciting the hypothesized favorable laryngeal and vocal tract configurations.

Key Dates

Start date

Dec 1, 2025

Status verified

Dec 2025

Primary completion

Jan 31, 2028

Completion

Jan 31, 2028

Study Design

Enrollment

60 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Other: Voice therapy
  Resonant voice therapy is a standard of care procedure for treating phonotraumatic vocal hyperfunction. The full standardized voice therapy program will have a duration of four weeks, each week with one 60-minute therapy session.

Primary Outcome Measure

Voice handicap index (VHI-10) [ Time Frame: 30 minutes before the first voice therapy session, and 30 minutes after the last session of the 4-week voice therapy ]

Central Contacts

• Zhaoyan Zhang
  3102064324
  [email protected]

Locations (1)

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