Brain Vascular and Neural Function Linked to Balance Across the Adult Lifespan

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT06127667
Status
Recruiting
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Conditions

  • Cognitively Normal
  • Neurotypical

Eligibility Criteria

Sex
ALL
Age
21 Years - 95 Years
Healthy Volunteers
Accepted

Interventions

  • aerobic exercise — BEHAVIORAL
    use of single bout of aerobic exercise

Study Details

This is a single-arm, two-visit, non-randomized, cross sectional study identified as an intervention due to the use of a single bout of aerobic exercise to assess cerebrovascular function under the NIH rules. This study is not masked and its primary purpose is to develop a basic science understanding of the relationship between cerebrovascular health and balance control with aging. This study will involve 102 individuals classified as younger adults, middle-aged adults, and older adults who are neurotypical and cognitively normal. The primary outcome from a clinical trials perspective will be cerebrovascular response to a bout of aerobic exercise (i.e. change in cerebral blood flow with the performance of aerobic exercise on a recumbent stepper exercise machine). Non-interventional outcomes will be EEG measures of cortical activity and biomechanical kinetic and kinematic data recorded during standing balance reactions, as well as biological blood samples for genomic analysis.

Key Dates

Start date
Oct 15, 2024
Status verified
Mar 2026
Primary completion
Jul 1, 2028
Completion
Jul 1, 2028

Study Design

Enrollment
102 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Experimental group
    Healthy participants in 3 age groups

Primary Outcome Measure

cerebral blood flow velocity assessed using transcranial Doppler ultrasound [ Time Frame: 1 week ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MinnesotaMinneapolisMinnesota55414
Jacqueline Palmer
[email protected]
240-446-1168

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