A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer

Part of paid clinical trials in Newnan, Georgia.

Sponsor
Johnson & Johnson Enterprise Innovation Inc.
Study ID
NCT06116786
Phase
PHASE1
Status
Recruiting
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Conditions

  • Carcinoma, Non-small-Cell Lung

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • JNJ-86974680 — DRUG
    JNJ-86974680 will be administered.
  • Cetrelimab — DRUG
    Cetrelimab will be administered.
  • Radiation Therapy — RADIATION
    Radiation therapy will be administered.

Study Details

The purpose of this study is to determine a safe and tolerable dose(s) of JNJ-86974680 for further research in combination with cetrelimab and radiation therapy.

Key Dates

Start date
Nov 27, 2023
Status verified
May 2026
Primary completion
Apr 14, 2027
Completion
Jun 7, 2029

Study Design

Enrollment
126 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Part 1: JNJ-86974680+Cetrelimab
    Participants will receive JNJ-86974680 alone (dose 1, dose 2, dose 3, and dose 4) daily in 4 cohorts and then along with a set dose of cetrelimab.
  • Experimental: Part 2: JNJ-86974680+Cetrelimab+Radiation Therapy (RT)
    Part 2 will consist of 3 cohorts (A, B and C) and participants will receive treatment with the selected dose of JNJ-86974680 in combination with cetrelimab from part 1, in conjunction with radiation.

Primary Outcome Measure

Number of Participants with Adverse Events (AEs) by Severity [ Time Frame: Up to 2 years 5 months ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
City of Hope 1NewnanGeorgia30265-
Hackensack University Medical CenterHackensackNew Jersey07601-
Roswell Park Comprehensive Cancer CenterBuffaloNew York14203-
Herbert Irving Comprehensive Cancer Center Columbia University Medical CenterNew YorkNew York10032-
Providence Portland Medical CenterPortlandOregon97213-
Thomas Jefferson UniversityPhiladelphiaPennsylvania19107-
Next VirginiaFairfaxVirginia22031-

Find similar trials in Newnan, GA

By research site
City of Hope 1· Newnan, GAHackensack University Medical Center· Hackensack, NJRoswell Park Comprehensive Cancer Center· Buffalo, NYHerbert Irving Comprehensive Cancer Center Columbia University Medical Center· New York, NYProvidence Portland Medical Center· Portland, ORThomas Jefferson University· Philadelphia, PA

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