StrokeCog-BBB to Study Cognitive Outcomes Following Stroke

Part of paid clinical trials in Palo Alto, California.

Sponsor
Stanford University
Study ID
NCT06116630
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
45 Years - 90 Years
Healthy Volunteers
Not accepted

Interventions

  • DCE-MRI — DIAGNOSTIC_TEST
    Both groups will undergo DCE-MRIs.

Study Details

The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.

Key Dates

Start date
May 17, 2022
Status verified
Apr 2024
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
350 participants (estimated)

Arms

  • Arm: Stroke
    Patients who have a history of stroke will be in the first group.
  • Arm: Control
    Patients who do not have a history of stroke, but have a history of cardiovascular risk factors will be in the second group.

Primary Outcome Measure

Correlation of leaky blood vessels in the brain and cognitive scores [ Time Frame: 4 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Stanford University HospitalPalo AltoCalifornia94304
Muhith Musabbir
650-723-8886

Find similar trials in Palo Alto, CA

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Stanford University Hospital· Palo Alto, CA

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