RESISTance Exercise for Depression Trial

Part of paid clinical trials in Ames, Iowa.

Sponsor
University of Wisconsin, Madison
Study ID
NCT06110897
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • High Dose Resistance Exercise Training — BEHAVIORAL
    Progressive resistance exercise training
  • Low Dose Resistance Exercise Training Group — BEHAVIORAL
    Progressive resistance exercise training

Study Details

Depression is a leading cause of disability worldwide and current treatments are ineffective for many people. This trial will investigate the efficacy of a 16-week high vs low dose resistance exercise training program for the treatment of Major Depressive Disorder (MDD) in 200 adults.

Key Dates

Start date
Jan 1, 2024
Status verified
Apr 2026
Primary completion
Nov 1, 2028
Completion
Oct 31, 2029

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: High Dose Resistance Exercise Training
    Participants will complete a 16-week, twice/week progressive program beginning at a moderate intensity. Each session will last \~60 minutes and begin and end with a 5-minute warm-up/cool-down. Training will begin with standard familiarization sessions to introduce participants to the machines, teach correct lifting techniques, and ensure participant safety and comfort with each exercise machine. Participants will perform 3 sets of 8-12 repetitions on 9 different machines (i.e., leg press, hamstring curl, quadriceps extension, chest press, lat pulldown, shoulder press, biceps curl, triceps extension) and one body weight/free-weight abdominal exercise. Workload will begin at 60% of estimated 1-RM and will systematically and progressively increase during the intervention.
  • Active Comparator: Low Dose Resistance Exercise Training
    Participants will complete a 16-week, twice/week progressive program beginning at a low intensity. Each session will last \~60 minutes and begin and end with a 5-minute warm-up/cool-down. Training will begin with standard familiarization sessions to introduce participants to the machines, teach correct lifting techniques, and ensure participant safety and comfort with each exercise machine. Participants will perform 3 sets of 8-12 repetitions on 9 different machines (i.e., leg press, hamstring curl, quadriceps extension, chest press, lat pulldown, shoulder press, biceps curl, triceps extension) and one body weight/free-weight abdominal exercise. Workload will begin at 30% of estimated 1-RM and will systematically and progressively increase during the intervention.

Primary Outcome Measure

Change in depressive symptom severity measured by GRID Hamilton Depression Rating Scale (GRID-HAM-D) [ Time Frame: Weeks 0, 8, 16, 26, 52 ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Iowa State UniversityAmesIowa50010-
University of Wisconsin - MadisonMadisonWisconsin53705
Taline Jouzi
[email protected]
608-890-0154

Find similar trials in Ames, IA

By condition
Depression
By specialty
PsychiatryMental healthBehavioral health
By research site
Iowa State University· Ames, IAUniversity of Wisconsin - Madison· Madison, WI

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