Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis

Part of paid clinical trials in El Paso, Texas.

Sponsor
University of Texas, El Paso
Study ID
NCT06105788
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
45 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise — OTHER
    Arm exercise will be an arm ergometer for 20 minutes, preceded by a 5-minute warm-up. Leg exercise will be a cycling ergometer for 20 minutes, preceded by a 5-minute warm-up. The exercise intensity will be set at 70% of the heart rate reserve (HRR) for each type of exercise.

Study Details

The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee osteoarthritis (OA). Furthermore, we will explore relations of socioeconomic status, racial discrimination, acculturative stress, and autonomic function to exercise effects on EIH, central pain mechanisms, and knee pain. This will be a pilot randomized cross-over study where all participants undergo Day 1 (baseline assessments), Day 2 (UE or LE), and Day 3 (UE or LE).

Key Dates

Start date
Nov 15, 2023
Status verified
Dec 2024
Primary completion
Oct 16, 2025
Completion
Oct 16, 2025

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Exercise
    Arm 1: All participants, knee OA and pain-free individuals, will undergo a single exercise of arm exercise using an arm ergometer and;
  • Active Comparator: Lower Body Exercise
    Arm 2: All participants, knee OA and pain-free individuals, will undergo a single exercise of leg exercise using a cycling ergometer.

Primary Outcome Measure

Changes in pressure pain thresholds (Measure of exercise-induced hypoalgesia) [ Time Frame: Day 1: PPT will be assessed twice. PPT assessment --> 25 minutes of waiting --> PPT assessment; Time frame of Days 2 and 3 will be the same except 25 minutes of waiting time. It will be 25 minutes of exercise (either AE or LE) on Days 2 and 3 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The University of Texas at El PasoEl PasoTexas79968
Kosaku Aoyagi, PhD
[email protected]
915-747-8215

Find similar trials in El Paso, TX

By condition
Osteoarthritis (other)
By specialty
OrthopedicsMusculoskeletal disorders
By research site
The University of Texas at El Paso· El Paso, TX

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