Psychotherapy Effects on Reward Processing in PTSD

Part of paid clinical trials in Austin, Texas.

Sponsor
University of Texas at Austin
Study ID
NCT06096740
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Cognitive Processing Therapy — BEHAVIORAL
    Cognitive processing therapy is a widely-utilized, empirically-supported treatment developed for PTSD. It is based on a cognitive theory of trauma which emphasizes the impact of trauma on belief systems and the development of "stuck points", which are unhealthy, unrealistic, and maladaptive ways of thinking that serve to maintain unhealthy beliefs and reinforce PTSD symptoms.

Study Details

The purpose of this study is to identify how trauma-focused psychotherapy changes the function of brain circuitry in posttraumatic stress disorder (PTSD) and how this mediates improvements in the diminished ability to experience positive emotions following a traumatic or extremely stressful life event. In this instance, the investigators will be using cognitive processing therapy (CPT), a widely-utilized and evidence-based treatment for PTSD.

Key Dates

Start date
Jun 1, 2024
Status verified
Sep 2025
Primary completion
Mar 1, 2029
Completion
May 1, 2029

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: Immediate Treatment
    Those individuals randomized to immediate treatment will commence individual cognitive processing therapy (CPT) with an assigned study therapist, following the completion of baseline procedures.
  • Placebo Comparator: Delayed Treatment
    Individuals randomized to the delayed treatment condition will be informed after randomization that their treatment will start in 6-8 weeks (the approximate period it will take for individuals in the immediate treatment arm to complete CPT and post-treatment assessments).

Primary Outcome Measure

Within subject beta coefficients for each parametrically modulated regressor of the Reinforcement Learning Task with Threat [ Time Frame: [10 weeks] ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600AustinTexas78712
Lauren Enten, B.S.A.
[email protected]
512-495-5856
Greg Fonzo, Ph.D. (PRINCIPAL_INVESTIGATOR)

Find similar trials in Austin, TX

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
Health Discovery Building (HDB), 1601 Trinity St., Bldg B., Z0600· Austin, TX

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