Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction

Part of paid clinical trials in New York, New York.

Sponsor
Weill Medical College of Cornell University
Study ID
NCT06096688
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

The primary aim of this study is to collect and store data, tissue, and personal and family histories from patients being screened for colorectal cancer and/or endometrial cancer at NYPH and WCM for routine clinical care and to make these available for future use for molecular and mechanistic studies.

Key Dates

Start date
May 29, 2019
Status verified
Aug 2025
Primary completion
May 29, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
1,120 participants (estimated)

Arms

  • Arm: FAP without treatment with NSAIDs
    Patients with the Hereditary Cancer Syndrome known as Familial Adenomatous Polyposis (FAP) undergoing upper or lower endoscopy/surgery without treatment with NSAIDs
  • Arm: FAP on treatment with NSAIDs
    Patients with the Hereditary Cancer Syndrome known as Familial Adenomatous Polyposis (FAP) undergoing upper or lower endoscopy/surgery on treatment with NSAIDs
  • Arm: HNPCC without treatment with NSAIDs
    Patients with the Hereditary Cancer Syndrome known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) undergoing lower endoscopy/surgery without treatment with NSAIDs
  • Arm: HNPCC on treatment with NSAIDs
    Patients with the Hereditary Cancer Syndrome known as Hereditary Non-Polyposis Colorectal Cancer (HNPCC) undergoing lower endoscopy/surgery on treatment with NSAIDs
  • Arm: Other Hereditary Colorectal Cancer Syndromes
    Other Hereditary Colorectal Cancer Syndromes undergoing lower endoscopy/surgery
  • Arm: Average-risk population
    Average-risk population undergoing lower endoscopy/surgery in the lower gastrointestinal tract.

Primary Outcome Measure

Novel mechanisms and genes inducing genetic predisposition to Hereditary Cancer Syndromes [ Time Frame: 7 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
NYP/Weill Cornell MedicineNew YorkNew York10065
Steven M Lipkin, MD, PhD
[email protected]
212-746-4014
Steven M Lipkin, MD, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in New York, NY

By condition
Colorectal cancerEndometrial cancer
By specialty
OncologyGI oncologyGynecologic oncologyWomen's health
By research site
NYP/Weill Cornell Medicine· New York, NY

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