Forebrain Electroneutral Transporters in Salt-sensitive Hypertension: an MRI Study

Conditions

• Salt-Sensitivity of Blood Pressure

Eligibility Criteria

Sex

ALL

Age

40 Years - 60 Years

Healthy Volunteers

Accepted

Interventions

• Furosemide (Diuretic) — DRUG
  The diuretic furosemide will be given during a 3% hypertonic saline infusion to examine blockade of the NKCC2.
• Hypertonic Saline Infusion — OTHER
  3% Hypertonic saline infusion to acutely increase sodium and osmolality

Study Details

The overall objective of this project is to identify the key salt-sensing regions of the brain and determine the underlying mechanism of sodium sensing. The investigators will assess how the brain responds to an acute increase of salt in the blood using MRI. This will be done during a 30-minute infusion of a saline solution containing 3% salt. One trial will be conducted with a salt sensing channel blocker and one trial without the salt sensing channel blocker. This will help to assess the role of a specific salt sensing channel in the brain. Salt sensitivity of BP will be assessed using 7-day dietary feeding where participants will be given food to consume for 7-days. Comparisons will be made between salt resistant (no change in blood pressure going from low to high salt diets) and salt sensitive adults (a change in blood pressure going from low to high salt diets). The investigators think the changes in MRI will be greater in salt sensitive compared to salt resistant subjects.

Key Dates

Start date

Mar 5, 2024

Status verified

Mar 2026

Primary completion

Jan 1, 2028

Completion

Jul 1, 2028

Study Design

Enrollment

120 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Salt Resistant Adults
  Adults who experience minimal BP change during dietary sodium challenge
• Experimental: Salt Sensitive
  Adults who experience increased BP (mean arterial pressures \>5mmHg) during dietary sodium challenge

Primary Outcome Measure

Bold fMRI [ Time Frame: 1 hour ]

Central Contacts

• Megan Wenner, PhD
  3028317343
  [email protected]
• Virginia Nuckols, PhD
  [email protected]

Locations (1)

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