A Drug-drug Interaction Study Evaluating the PK Effects of Obicetrapib on Atorvastatin and Rosuvastatin
- Sponsor
- NewAmsterdam Pharma
- Study ID
- NCT06081166
- Phase
- PHASE1
- Status
- Completed
Conditions
- Healthy Volunteers
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 65 Years
- Healthy Volunteers
- Accepted
Interventions
- Obicetrapib — DRUGobicetrapib 10 mg daily
- Atorvastatin Calcium — DRUGAtorvastatin 80 mg
- Rosuvastatin Calcium — DRUGRosuvastatin 40 mg
Study Details
A study to evaluate impact of Obicetrapib on PK levels of Atorvastatin and Rosuvastatin
Key Dates
- Start date
- Nov 11, 2023
- Status verified
- Oct 2023
- Primary completion
- Dec 2, 2023
- Completion
- Jan 22, 2024
Study Design
- Enrollment
- 74 participants (actual)
- Allocation
- NON_RANDOMIZED
- Intervention model
- SEQUENTIAL
- Primary purpose
- TREATMENT
Arms
- Active Comparator: obicetrapib + atorvastatinObicetrapib 10 mg tablets daily from Days 1-17 plus atorvastatin calcium 80 mg tablets on Day -4 and Day 12
- Active Comparator: obicetrapib + rosuvastatinObicetrapib 10 mg tablets daily from Days 1-17 plus rosuvastatin calcium 40 mg tablets on Day -4 and Day 12
Primary Outcome Measure
Measure atorvastatin/rosuvastatin levels in the blood [ Time Frame: zero (0) to time of the last measurable analyte concentration (t), up to 22 days ]
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