The Computational and Neural Mechanisms Linking Decision-making and Memory in Humans

Conditions

• Memory, Short-Term

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Not accepted

Interventions

• Value-manipulation — BEHAVIORAL
  During the decision-making task, different choices are assigned different values probabilistically.

Study Details

Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL's influence on memory, the researcher will record local field potential (LFP) and single neuron activity in various brain regions as epilepsy patients perform the proposed task. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes.

Key Dates

Start date

Oct 31, 2023

Status verified

Dec 2025

Primary completion

Sep 1, 2028

Completion

Sep 1, 2028

Study Design

Enrollment

50 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Value-manipulation
  Participants with epilepsy will complete a behavioral task in which they use a laptop computer to do a decision-making and memory task.

Primary Outcome Measure

Local-field potentials changes [ Time Frame: During task participation, approx. 30-45 min in the first 2 weeks of hospital stay ]

Central Contacts

• Salman E Qasim, PhD
  212-824-9531
  [email protected]

Locations (1)

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