Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1

Conditions

• Post-Traumatic Headache

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Bupivacaine Injection — DRUG
  subcutaneous injection around bilateral greater occipital nerves

Study Details

The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared. Each Veteran participant will be randomized to receive three different concentrations, which will be injected one week apart each.

Key Dates

Start date

Jan 26, 2024

Status verified

Jan 2026

Primary completion

Dec 31, 2026

Completion

Dec 31, 2026

Study Design

Enrollment

12 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Arms

• Experimental: Group 1
  bupivacaine 0.0%, 0.01%, and 0.05% in random order, one week apart each
• Experimental: Group 2
  bupivacaine 0.1%, 0.05%, and 0.1% in random order, one week apart each
• Experimental: Group 3
  bupivacaine 0.0%, 0.1%, and 0.5% in random order, one week apart each
• Experimental: Group 4
  bupivacaine \[0.01% or 0.05%\], \[0.05% or 0.1%\], and 0.05% in random order, one week apart each

Primary Outcome Measure

Acute sensation felt during injection: quality [ Time Frame: During injection ]

Central Contacts

• Emmanuelle Schindler, MD, PhD
  203-932-5711
  [email protected]

Locations (1)

Find similar trials in West Haven, CT

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