Study of Radiotherapy and Pembrolizumab in People With Adrenocortical Carcinoma

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT06066333
Phase
PHASE2
Status
Recruiting
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Conditions

  • ACC
  • Adrenocortical Carcinoma
  • Metastatic Adrenocortical Carcinoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Ablative Radiotherapy — RADIATION
    All participants will first undergo ablative RT
  • Pembrolizumab — DRUG
    After completion of ablative RT, all subjects may begin pembrolizumab treatment

Study Details

The purpose of this study is to determine whether pembrolizumab given after standard ablative Radiotherapy is a safe treatment that causes few or mild side effects in people with advanced Adrenocortical Carcinoma.

Key Dates

Start date
Sep 27, 2023
Status verified
Apr 2026
Primary completion
Sep 27, 2026
Completion
Sep 27, 2026

Study Design

Enrollment
12 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants with Adrenocortical Carcinoma
    Participants with histologically proven metastatic Adrenocortical Carcinoma/ACC with both intra-hepatic and extra-hepatic sites of disease.

Primary Outcome Measure

Number of participants evaluated for AEs [ Time Frame: up to 1 year ]

Central Contacts

Locations (7)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (All Protocol Activities)Basking RidgeNew Jersey07920
Nitya Raj, MD
646-888-4849
Memorial Sloan Kettering Monmouth (All Protocol Activities)MiddletownNew Jersey07748
Nitya Raj, MD
646-888-4849
Memorial Sloan Kettering Bergen (All Protocol Activities)MontvaleNew Jersey07645
Nitya Raj, MD
646-888-4849
Memorial Sloan Kettering Suffolk-CommackCommackNew York11725
Nitya Raj, MD
646-888-4849
Memorial Sloan Kettering Westchester (All Protocol Activities)HarrisonNew York10604
Nitya Raj, MD
646-888-4849
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065
Nitya Raj, MD
646-888-4849
Memorial Sloan Kettering Nassau (All Protocol Activities)UniondaleNew York11553
Nitya Raj, MD
646-888-4849

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Memorial Sloan Kettering Basking Ridge (All Protocol Activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All Protocol Activities)· Middletown, NJMemorial Sloan Kettering Bergen (All Protocol Activities)· Montvale, NJMemorial Sloan Kettering Suffolk-Commack· Commack, NYMemorial Sloan Kettering Westchester (All Protocol Activities)· Harrison, NYMemorial Sloan Kettering Cancer Center (All Protocol Activities)· New York, NY

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